Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain. The resulting ...

Researchers know that ApoE4 and Trem2 can worsen neurodegeneration in mouse models of tauopathy. Do these proteins conspire to exacerbate pathology? It turns out that ApoE4 causes much of the damage ...

Brain atrophy (cerebral atrophy) is the loss of brain cells called neurons, as well as the connections that help cells communicate. It can result from different diseases that damage the brain. As you ...

In the brains of carriers of familial Alzheimer’s disease mutations, Aβ starts accumulating in some regions more than two decades before symptoms appear, metabolism wanes six years later, and the ...

In 2020, Ashley Harms, Ph.D., and University of Alabama at Birmingham colleagues published an Acta Neuropathologica study that used a mouse model to show that the alpha-synuclein pathology from ...