Cell death in dementia has long posed a frustrating problem. Toxic proteins pile up inside neurons in Alzheimer’s disease and ...

The team worked for 10 years to uncover the hidden brain-cell death process fueling several dementias, revealing a key new ...

Markers of a new mechanism for cell death, called karyoptosis, have been found in the brains of patients with Alzheimer's ...

Caspases are evolutionarily conserved cysteine proteases that cleave their substrates at specific aspartic acid residues, playing a central role in programmed cell death (PCD) 1. These enzymes are ...

AbstractNon apoptotic cell death programs particularly ferroptosis and cuproptosis are transforming how we understand cancer ...

Taking ROS as the core node connecting cell death pathways and therapeutic strategies Exploring innovative therapeutic strategies targeting the ROS-cell death network, providing a new direction for ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

Scientists discover karyoptosis, a new cell death mechanism causing nuclear disintegration in Alzheimer's and frontotemporal ...

Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central regulators of programmed cell death pathways, undergo precise modulation ...

As we age, our ability to maintain healthy blood and a strong immune system gradually declines, largely because hematopoietic stem cells (HSCs), the cells responsible for producing all blood cell ...