One of the first intracellular kinases to be explicated as a protooncogene was c-Src, an upstream mediator of both the PI 3-K and MAPK pathways. The amplified c-Src activity has been implicated in ...

The LAT Signalosome The models summarized in the Antigen Discrimination and Intracellular Receptor Phopshorylation sections describe T-cell activation up to the point of ZAP-70 binding to the ...

Host species have evolved mechanisms that can inhibit pathogen replication even after a cell has been successfully invaded. Here we show that tripartite-motif protein 21 (TRIM21), a ubiquitously ...

Announcing a new article publication for Zoonoses journal. Researchers from University of Texas Medical Branch, Galveston, TX, USA review pattern recognition receptors in innate immunity to obligate ...

Signal transduction is the term for the process which causes chemical and physical signals to be transmitted within a cell as a series of molecular events. The most common signal transduction process ...