The research team developed a genetically engineered mouse model carrying a mutation (E3896A) in RyR1, which disrupts its calcium-binding site, effectively disabling CICR while preserving ...

Intracellular Ca 2+ is pivotal in various aspects of cell physiology, including neuronal transmission, apoptosis, gene transcription, and cell migration 1,2. The essential role of Ca 2+ is underscored ...

The occurrence of diseases characterized by irregular spinal alignment, such as kyphosis, lordosis, scoliosis, and dropped head syndrome (DHS) is increasing, particularly among older adults. DHS is ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...

Space exploration activity has been increasing. In turn, researchers are more interested than ever in uncovering more about how space travel affects human health and the progression of disease.