Rounding out the afternoon in the late window for Week 5 will be Tennessee at Arizona, Detroit in Cincinnati, taking on the Bengals, and Washington visiting the West Coast to face the Los Angeles Chargers. It's Week 5, and the NFL is down to its final two undefeated teams in the Eagles and Buffalo Bills.

Create the best lineup on DraftKings for Sunday’s NFL Main Slate of games and take home the million-dollar first prize

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The Baltimore Ravens are limping into a Week 5 matchup with the visiting Houston Texans, missing five All-Pro players. Quarterback Lamar Jackson, linebacker Roquan Smith, and safety Kyle Hamilton are all out for Sunday's game with hamstring injuries.

Injuries are often the biggest enemy of fantasy football managers, and we've seen plenty of significant ones already in the 2025 NFL season. Malik Nabers and Tyreek Hill were the latest superstars to go down for the season,

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Let's update our NFL Power Rankings ahead of Week 10. Plus, we picked out critical games remaining on the schedule for every team.