A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has ...

Taste, pain, or response to stress — nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the University of ...

Breaking a longstanding impasse in our understanding of olfaction, scientists at UC San Francisco have created the first molecular-level, 3D picture of how an odor molecule activates a human odorant ...

Olfactory receptors (ORs), the largest family within the G protein–coupled receptor (GPCR) superfamily, have long been recognized for their essential ...

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new ...

Breaking a longstanding impasse in our understanding of olfaction, scientists at UC San Francisco (UCSF) have created the first molecular-level, 3D picture of how an odor molecule activates a human ...

Receptor proteins, expressed on the cell surface or within the cell, bind to different signaling molecules, known as ligands, initiating cellular responses. Taste receptors, expressed in oral tissues, ...

Researchers have uncovered how a protein called MRAP2 acts as a key regulator of hunger. It helps move the appetite receptor MC4R to the cell’s surface, allowing it to send stronger “stop eating” ...

Researchers used GPS-like tracking to observe how a key G protein-coupled receptor (GPCR) moves, revealing the core mechanism behind vital body functions. G protein-coupled receptors are embedded in ...