Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and development. The study is published in the journal Nature Communications. The ...

Based on current data, colorectal cancer (CRC) ranks third globally in terms of cancer incidence. Over 1.9 million new cases and 930,000 fatalities related to CRC were reported in 2020. According to ...

Invasion experiments were conducted as described [10], except that 1 × 10 5 single organoid cells were dispensed into transwell inserts (#353097, Corning Life Sciences, Corning, New York, USA). After ...

The liver's ability to communicate with other organs is crucial for maintaining homeostasis, particularly through signaling pathways. During liver regeneration, communication with organs such as the ...

A new research paper was published in Genes & Cancer on February 5, 2023, entitled, "Mechanistically based blood proteomic markers in the TGF-β pathway stratify risk of hepatocellular cancer in ...

MicroRNA analysis of fine-needle aspirates from pancreatic cancer. Background: TGF-beta acts both as a tumor suppressor or tumor promoter depending upon cellular context and stage of tumor progression ...

Schematic representation of different strategies targeting TGF-β signaling for liver fibrosis therapy. TGF-β signaling inhibitors hold important therapeutic potential for hepatic fibrosis. Although ...

Suppression of the TGF-β/Smad pathway via a Smad7/Smurf2-dependent ubiquitination mechanism, and direct disruption of the apoptosis-resistant barrier in HSCs. This work extends the role of CTSK beyond ...

Mouse Avatar Models of Colorectal Cancer Liver Metastasis: The Molecularly Annotated Platforms for Preclinical Evaluation of Novel Therapeutics Background: Oral squamous cell carcinoma (OSCC) is a ...

Over the past few decades, the idea of modifying a patient’s own immune cells to recognize and destroy cancer has evolved from concept to reality. So-called “adoptive T cell therapy” has emerged as ...