Titin is the third most abundant protein in muscle (after myosin and actin), and an adult human contains approximately 0.5 kg of titin. [13] With its length of ~27,000 to ~35,000 amino acids (depending on …

Jan 2, 2025 · This review examines the giant elastic protein titin and its critical roles in heart function, both in health and disease, as discovered since its identification nearly 50 years ago.

The TTN gene provides instructions for making a very large protein called titin. Learn about this gene and related health conditions.

Jul 21, 2025 · An adult human body contains about 0.5 kg of titin, making it the third most abundant protein in muscle tissue, following only actin and myosin. A single molecule of titin is over 1 …

Titin is the largest protein chain in your body, with more than 34,000 amino acids. This titanic protein acts like a big rubber band in our muscles. It is attached at one end to the Z-disk (shown here at the …

May 2, 2022 · Titin, also called connectin, is the largest known protein. It is found in the striated muscle tissue of humans and other vertebrates; homologous proteins exist in invertebrate animal families.

Apr 10, 2024 · With a molecular weight of ∼3–4 MDa (in humans), titin is the largest protein expressed in mammals, extending from the Z-disk to the M-band where the N- and C-termini are anchored, …

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.

Oct 18, 2021 · The overall goal of our review is to explore how cardiac titin properties can be changed at a molecular level, with an emphasis on titin stiffness and protein quality control (PQC), and how this …

Titin is a filamentous protein spanning the half-sarcomere, with spring-like properties in the I-band region. Various structural, signaling, and mechanical functions have been associated with titin, but …