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Come Experience the New South Old Charm in Picayune MS. Picayune Main Street, Inc. Mission is to enhance our community and encourage investment in Picayune. We focus our attention and resources in the heart of the city. Throughout the year, Picayune Main Street, Inc. sponsors events in Downtown Picayune, MS to help support a vibrant shopping and dining district and create a place that attracts people and inspires everyone to Enjoy Events, Arts, Antiques, Shop, Dine & Play Local while experiencin
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